MelanoDet proposes an innovative solution for the early detection of melanomas using non-invasive multispectral imaging techniques. The solution will materialize both by building the MelanoDet acquisition system and by delivering a software package that returns a risk score for a specific lesion under investigation. Another innovative element of the project consists in combining the acquisition of static images in the infrared and visible domains and thermal domains, by recording, in real time, a video sequence that highlights the dynamics of the thermoregulatory effect from the skin when a cold stimulus is applied on the region of interest.